Research
Hormonal
SIRT1 overexpression induces rapid muscle hypertrophy in fed, normal mice without activating the PI3K-AKT signaling pathway.
SIRT1 can promote muscle growth through a unique mechanism that bypasses the usual growth signals (like insulin/IGF-1). This suggests that metabolic health and SIRT1 activity are crucial for maintaining muscle size, independent of traditional strength training signals.
GoodSupportsHIGH confidence
In normal muscle, SIRT1 overexpression by electroporation causes rapid fiber hypertrophy without, surprisingly, activation of the PI3K-AKT signaling pathway. Thus, SIRT1 activation favors postnatal muscle growth...
Why this rating
Consistent in vivo animal data showing hypertrophy and lack of AKT activation.
Source
SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth
Dong Hoon Lee et al. · Journal of Biological Chemistry · 2013
DOI 10.1074/jbc.m113.489716
mechanism_onlyCited 209×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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