Hormonal
In women, short sleep duration (≤5 hours) is associated with significantly higher levels of high-sensitivity C-reactive protein (hs-CRP) compared to 7 hours of sleep, whereas no such association exists in men.
If you are a woman, consistently sleeping 5 hours or less is linked to higher levels of hs-CRP, a marker of inflammation and cardiovascular risk, compared to sleeping 7 hours. This specific inflammatory risk was not observed in men in this study. Prioritizing 7-8 hours of sleep may be particularly important for managing inflammation in women.
However, there was a significant nonlinear association in women, the level of hs-CRP being significantly higher in women short sleepers (5 hours or less) after multiple adjustments (P = 0.04) (interaction P < 0.05).
Why this rating
Large sample size (n=4677 for hs-CRP), rigorous adjustment for confounders (BMI, smoking, BP, lipids), but limited by cross-sectional design and self-reported sleep data.
Source
Gender Differences in the Cross-Sectional Relationships Between Sleep Duration and Markers of inflammation: Whitehall II Study
Michelle A. Miller et al. · SLEEP · 2009
DOI 10.1093/sleep/32.7.857
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