Hormonal
Pharmacological induction of autophagy by spermidine and resveratrol extends the lifespan of model organisms (yeast, nematodes, flies) and improves fitness in human cells, a process that is strictly dependent on the activation of autophagy pathways.
Current evidence supports that spermidine and resveratrol extend lifespan in model organisms by triggering autophagy. However, direct application to human longevity is not yet proven. Focus on maintaining cellular health through known autophagy inducers like exercise and fasting, which share mechanistic similarities.
These beneficial effects are lost when essential autophagy modulators are genetically or pharmacologically inactivated, indicating that autophagy is required for the cytoprotective and/or anti-aging effects of spermidine and resveratrol.
Why this rating
Strong evidence in yeast, nematodes, and flies; evidence in mice is mixed (requires high-fat diet for resveratrol); human data is limited to cell culture fitness.
Source
Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol
Eugenia Morselli et al. · Aging · 2009
DOI 10.18632/aging.100110
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