Hormonal
Bariatric surgery-induced weight loss in morbidly obese patients significantly improves insulin sensitivity, endothelial function, and specific inflammatory markers (CRP, sialic acid, E-selectin, P-selectin, vWF, PAI-1), although proinflammatory cytokines (TNF-alpha, IL-6) may remain elevated.
For morbidly obese individuals, bariatric surgery can significantly improve insulin sensitivity and endothelial function within months, reducing cardiovascular risk. However, not all inflammatory markers (like TNF-alpha and IL-6) may normalize, suggesting that metabolic stress or residual adiposity might sustain some inflammatory pathways. This highlights the importance of addressing insulin resistance specifically.
In conclusion, a marked improvement in SI, endothelial function, and low grade inflammation was observed in the weight-losing, morbidly obese patients after bariatric surgery. SI and adiposity appear to play roles in obesity-related, low grade inflammation that contribute to the endothelial dysfunction observed in morbid obesity.
Why this rating
Randomized controlled trial design with a matched control group, though the intervention is surgical rather than lifestyle-based.
Source
Effects of Changes in Body Weight and Insulin Resistance on Inflammation and Endothelial Function in Morbid Obesity after Bariatric Surgery
Luis Alberto Vázquez et al. · The Journal of Clinical Endocrinology & Metabolism · 2005
DOI 10.1210/jc.2003-032059
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