Hormonal
Insulin regulates free fatty acid (FFA) appearance in plasma primarily by inhibiting lipolysis, while maintaining a constant absolute rate of primary intra-adipocyte FFA reesterification.
Insulin controls blood fat levels mostly by stopping fat cells from releasing fat, not by burning it. This happens at relatively low insulin levels. High insulin levels are needed to significantly change how much fat your muscles burn. For weight management, keeping insulin levels stable helps prevent fat release from adipose tissue.
In conclusion, insulin regulates FFA Ra by inhibition of lipolysis while maintaining a constant rate of primary FFA reesterification.
Why this rating
Controlled human clinical trial with isotope dilution and indirect calorimetry.
Source
Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification
Peter J. Campbell et al. · American Journal of Physiology-Endocrinology and Metabolism · 2006
DOI 10.1152/ajpendo.2006.263.6.e1063
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →