Macro partitioning

Heterozygosity for the UCP3 exon 6-splice donor-stop polymorphism reduces basal fat oxidation by 50% and increases the respiratory quotient, indicating a metabolic shift toward carbohydrate oxidation and fat storage.

If you carry this specific UCP3 genetic variant, your body is genetically predisposed to burn less fat and store more carbohydrates at rest. This does not mean you are doomed to obesity, but it suggests that managing carbohydrate intake and maintaining physical activity to stimulate fat oxidation may be more critical for you than for someone without this variant. Focus on dietary patterns that support metabolic flexibility.