Macro partitioning
Visceral adipose tissue (VAT) and epicardial adipose tissue (EAT) accumulation is a primary driver of cardiovascular injury in obesity and diabetes, independent of overall body mass index (BMI), through the release of pro-inflammatory factors and free fatty acids.
For individuals with obesity or Type-2 Diabetes, focusing solely on BMI is insufficient for assessing heart disease risk. Visceral and epicardial fat are more dangerous indicators. Reducing these specific fat depots through lifestyle changes or medication is crucial for preventing heart failure and other cardiovascular injuries.
Recent data suggest that both body fat distribution and adipocyte phenotype, can be more determinant for fatal outcomes in obese patients than increased general adiposity. In particular, visceral adiposity is significantly linked to long term alterations on different cardiac structures...
Why this rating
Supported by multiple large-scale clinical studies (MESA, Health ABC, Cardiovascular Health) cited in the review.
Source
Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes
Nieves González et al. · Cardiovascular Diabetology · 2017
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