Research
Hormonal
FGF21 analogs exert direct anti-inflammatory effects in NASH by suppressing pro-inflammatory cytokine expression (TNF-a, IL-6, IL-1b) and inhibiting immune cell infiltration into the liver.
FGF21 analogs help reduce liver inflammation by blocking the signals that recruit immune cells and produce damaging cytokines. This helps prevent the progression from fatty liver to scarring (fibrosis).
ModerateSupportsMEDIUM confidence
FGF21 suppresses inflammation in NASH models... FGF21 inhibits macrophage expression of the pro-inflammatory cytokines TNF-a, IL-6, IL-1b, and IFN-g by inducing NRF2 nuclear translocation, thereby blocking NF-kB activation.
Why this rating
Evidence is derived from preclinical animal models and cell-based studies.
Source
FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases
Erik J. Tillman et al. · Frontiers in Endocrinology · 2020
DOI 10.3389/fendo.2020.601290
narrative_reviewCited 204×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- FGF21 analogs reduce hepatic steatosis and lipotoxicity in NASH by suppressing de novo lipogenesis and increasing mitochondrial fatty acid oxidation, independent of weight loss.Moderate
- Endogenous FGF21 levels are elevated in NASH patients but are insufficient to ameliorate disease due to a 'FGF21-resistant state' caused by receptor downregulation and enzyme-mediated inactivation.Moderate
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