Hormonal
Glucagon receptor signaling regulates hepatic lipid metabolism by stimulating beta-oxidation and inhibiting lipogenesis, thereby reducing hepatic lipid accumulation.
Glucagon plays a crucial role in how your liver handles fat. While high glucagon in diabetes can be problematic, activating glucagon receptors (especially when combined with GLP-1) helps the liver burn fat and reduces liver fat storage. This is why combination therapies are effective for metabolic health.
Glucagon acts primarily on the liver and by regulating hepatic lipid metabolism glucagon may reduce hepatic lipid accumulation and decrease hepatic lipid secretion.
Why this rating
The paper is a mini-review citing multiple consistent animal models (Gcgr-/- mice) and human studies, though human adipocyte data is conflicting.
Source
Glucagon Receptor Signaling and Lipid Metabolism
Katrine D. Galsgaard et al. · Frontiers in Physiology · 2019
DOI 10.3389/fphys.2019.00413
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