Research
Hormonal
Antiandrogen treatment with spironolactone (SP) in obese postmenopausal women undergoing weight loss results in a smaller loss of subcutaneous abdominal fat compared to placebo, with no significant improvement in visceral fat loss.
Taking spironolactone (75mg daily) during weight loss does not appear to offer any advantage in fat loss or body composition for obese postmenopausal women compared to diet alone. It may even result in less total fat loss.
GoodRefutesHIGH confidence
The SP group lost fat at 3 months, but by 9 months had regained it so that, in total, they lost significantly less body fat than the PL and ND groups... The SP group had significantly more SC fat than the ND group at 9 months
Why this rating
Randomized, placebo-controlled clinical trial.
Source
Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women--a clinical research center study.
Jennifer C. Lovejoy et al. · The Journal of Clinical Endocrinology & Metabolism · 1996
DOI 10.1210/jcem.81.6.8964851
rct · n=30Cited 203×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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