Hormonal
In patients with ileum resected short bowel syndrome and a preserved colon, endogenous plasma concentrations of GLP-1 and GLP-2 are significantly elevated compared to healthy controls, contributing to functional intestinal adaptation.
For patients with extensive small bowel removal, keeping the colon is physiologically critical. The colon's L cells secrete high levels of GLP-1 and GLP-2 when nutrients reach them, which slows digestion and promotes intestinal growth. This natural hormonal response is a key reason why patients with a preserved colon have better outcomes than those without.
Ileum resected short bowel patients with a preserved colon had elevated fasting plasma concentrations of GLP-1 and GLP-2 and significantly larger meal stimulated areas under the curve compared with age and sex matched controls. Elevated GLP-1 and GLP-2 concentrations may contribute to the positive Effects of a preserved colon on intestinal motility and functional adaptation in ileum resected short bowel patients.
Why this rating
Small sample size (n=7 per group) but rigorous within-subject and matched-control design with specific radioimmunoassays.
Source
Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
Palle Bekker Jeppesen et al. · Gut · 2000
DOI 10.1136/gut.47.3.370
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