Hormonal
Certain pharmaceutical drugs (ACE inhibitors, statins, mTOR inhibitors) and lifestyle interventions (exercise) can increase circulating Klotho levels, potentially offering therapeutic benefits for age-related diseases.
Regular physical activity and adherence to prescribed medications for blood pressure, cholesterol, or metabolic health may naturally support higher Klotho levels. This suggests that standard health maintenance practices contribute to longevity mechanisms.
In clinical trials, increased Klotho was noted with renin-angiotensin system inhibitors (losartan, valsartan), a statin (fluvastatin), mTOR inhibitors (rapamycin, everolimus)... Notably, exercise and sport activity increased Klotho.
Why this rating
Evidence is mixed between strong preclinical data and observational human clinical trial data; direct causal links to improved outcomes via Klotho elevation are still being investigated.
Source
Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
Gérald J. Prud’homme et al. · Frontiers in Aging · 2022
DOI 10.3389/fragi.2022.931331
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