Research
Hormonal
Muscle aging involves distinct molecular processes (post-transcriptional changes, PGR/RXR activation) that are separate from those regulated by physical activity.
Exercise is beneficial for muscle health, but it may not reverse the specific molecular changes associated with aging. Understanding these distinct pathways could lead to targeted therapies for age-related muscle loss (sarcopenia) that complement exercise.
GoodSupportsHIGH confidence
human muscle age-related molecular processes appear distinct from the processes regulated by those of physical activity
Why this rating
Based on multiple independent cohorts (n=45, n=52) and rigorous statistical analysis (QSAM), providing robust evidence for distinct molecular signatures.
Source
Molecular Networks of Human Muscle Adaptation to Exercise and Age
Bethan E. Phillips et al. · PLoS Genetics · 2013
DOI 10.1371/journal.pgen.1003389
cohort · n=141Cited 202×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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