Hormonal
Older adults exhibit blunted muscle hypertrophy in response to resistance exercise training due to synchronous deficits in long-term muscle protein synthesis and ribosomal biogenesis, rather than just acute signaling issues.
If you are older, expect your muscles to grow slower than when you were young. This is a biological reality called 'anabolic resistance,' driven by hormonal changes and cellular efficiency, not a lack of effort. Focus on consistency and strength gains, which older adults can still achieve significantly, even if muscle size increases are blunted compared to younger individuals.
In response to 6 weeks RET, we found blunted hypertrophic responses with age are underpinned by chronic deficits in long-term muscle protein synthesis. We show this is likely to be the result of multifactorial deficits in anabolic hormones and blunted translational efficiency and capacity.
Why this rating
Randomized controlled trial with objective measures (D2O labeling, biopsies) comparing young vs. old, though sample size is small (n=20).
Source
Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans
Matthew S. Brook et al. · The Journal of Physiology · 2016
DOI 10.1113/jp272857
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