Hormonal
Inhibition of cyclooxygenase (COX) activity prevents the induction of UCP1 in white adipose tissue (WAT), thereby reducing diet-induced thermogenesis and promoting increased adiposity.
This research suggests that chronic use of COX inhibitors (like indomethacin, and potentially NSAIDs like ibuprofen) might interfere with your body's ability to burn fat through 'browning' of white fat, especially if you are not exercising in cold environments. For most people, occasional use is fine, but if you are trying to maximize metabolic efficiency, be aware that these drugs might blunt a specific fat-burning pathway.
Inhibition of COX activity attenuated diet-induced UCP1 expression and increased energy efficiency and adipose tissue mass in obesity-resistant mice kept at thermoneutrality.
Why this rating
Strong mechanistic evidence in mice (KO models, inhibitors, cell lines), but extrapolation to humans requires caution.
Source
UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity
Lise Madsen et al. · PLoS ONE · 2010
DOI 10.1371/journal.pone.0011391
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