Hormonal
Females have greater basal autophagy activity but lower basal ubiquitin-proteasome activity compared to males, leading to different catabolic responses during muscle stress.
Your body's internal 'clean-up' systems for muscle proteins work differently than a man's. You may rely more on autophagy (cellular recycling) while men rely more on the ubiquitin-proteasome system. This is a biological baseline difference driven by hormones and doesn't necessarily require intervention, but it explains why muscle responses to stress can vary.
While females tend to have less ubiquitin-proteasome activity compared to males, females tend to have greater autophagy-related protein degradation compared to males
Why this rating
Based on molecular studies showing differential expression of catabolic pathway markers.
Source
Muscle metabolism and atrophy: let’s talk about sex
Megan E. Rosa‐Caldwell et al. · Biology of Sex Differences · 2019
DOI 10.1186/s13293-019-0257-3
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