Hormonal
Resistance exercise-induced skeletal muscle hypertrophy is not solely dependent on rapamycin-sensitive mTOR signaling, as inhibiting this pathway only partially blocks muscle growth and protein synthesis.
You don't need to obsess over optimizing every single molecular signal to build muscle. While mTOR is important, your body has backup systems that allow muscle growth even if this specific pathway is dampened. Focus on consistent resistance training rather than trying to perfectly manipulate one specific biological mechanism.
the inhibition of rapamycin-sensitive mTOR only partially blocked the hypertrophic effects of chronic RE... Combined, the results from this study not only establish that rapamycin-sensitive mTOR plays an important role in the RE-induced activation of protein synthesis and the induction of hypertrophy, but they also demonstrate that additional (rapamycin-sensitive mTOR-independent) mechanisms contribute to these fundamentally important events.
Why this rating
High-quality rodent model with rigorous controls, specific pharmacological inhibition (rapamycin), and multiple endpoints (protein synthesis, hypertrophy, signaling markers), though translational to humans requires caution.
Source
The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise
Riki Ogasawara et al. · Scientific Reports · 2016
DOI 10.1038/srep31142
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