Hormonal
Circadian misalignment induces a gene expression profile in skeletal muscle that favors fatty acid metabolism over glucose metabolism, potentially leading to substrate competition and reduced insulin sensitivity.
Your muscles change how they use fuel based on your schedule. When you are misaligned (e.g., working nights), your muscles switch to burning more fat and less glucose, which can interfere with insulin's ability to store glucose. This is driven by changes in gene expression. Maintaining a consistent schedule helps keep your muscle metabolism balanced.
transcriptome analysis revealed the human PPAR pathway as a key player in the disturbed energy metabolism upon circadian misalignment... fatty acid metabolism and PPAR signaling are most strongly increased from 7 AM to 7 PM in the misaligned condition
Why this rating
Robust transcriptomic analysis with pathway enrichment, but the causal link to insulin resistance is inferred from gene expression rather than direct functional validation in humans.
Source
Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle
Jakob Wefers et al. · Proceedings of the National Academy of Sciences · 2018
DOI 10.1073/pnas.1722295115
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