Research
Hormonal
Fasting increases hypothalamic Sirt1 expression and activity, which deacetylates FoxO1 to regulate the central melanocortin system.
Fasting increases the activity of Sirt1 in the brain, which helps regulate hunger signals through the FoxO1 pathway. This suggests that the body's response to fasting involves specific molecular changes in the hypothalamus.
ModerateSupportsMEDIUM confidence
We also showed that fasting increases hypothalamic Sirt1 expression and decreases FoxO1 (Forkhead transcription factor) acetylation suggesting that Sirt1 regulates the central melanocortin system in a FoxO1 dependent manner.
Why this rating
Based on rodent models and in vitro cell lines.
Source
Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
Işın Çakır et al. · PLoS ONE · 2009
DOI 10.1371/journal.pone.0008322
mechanism_onlyCited 194×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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