Hormonal
Time-Restricted Feeding (TRF) shows profound metabolic benefits in rodents (improved glucose tolerance, reduced adiposity/steatosis) even without energy restriction, but human studies are sparse, mixed, and methodologically limited, with some showing worsened glycaemia.
If you try Time-Restricted Feeding (TRF), limit your eating window to 10-12 hours daily. Be aware that human evidence is mixed; some studies show worsened glycaemia, possibly due to timing (e.g., evening eating) or methodological issues. Monitor your blood glucose and lipids, and consider experimenting with earlier eating windows if possible, as this may align better with circadian biology.
Whilst the metabolic benefits of TRF appear quite profound in rodents, findings from the few human studies have been mixed... In this instance, oral glucose tolerance testings were conducted in the morning... there was significant elevations in fasting and postprandial glycaemia.
Why this rating
Human data is described as 'sparse' and 'methodologically limited', with conflicting results (some improved, some worsened glycaemia).
Source
Effects of intermittent fasting on glucose and lipid metabolism
Rona Antoni et al. · Proceedings of The Nutrition Society · 2017
DOI 10.1017/s0029665116002986
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