Research
Hormonal
Activation of PPARg increases lipid storage capacity in adipose tissue, thereby preventing lipotoxicity and improving insulin sensitivity.
Medical treatments that activate PPARg (like TZDs) work by forcing fat cells to store more fat safely, keeping it out of the liver and muscles where it causes damage.
GoodSupportsHIGH confidence
Activation of PPARg stimulates storage of fatty acids in mature adipocytes... These pharmacological ligands induce adipocyte differentiation, and thus increase the number of adipocytes expressing GLUT4 glucose transporters and increase lipogenic genes... reducing circulating FFAs.
Why this rating
Supported by mouse knockout models and clinical use of TZDs.
Source
Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor γ (PPARγ) and PPARγcoactivator-1 (PGC1)
Gema Medina‐Gómez et al. · Public Health Nutrition · 2007
DOI 10.1017/s1368980007000614
narrative_reviewCited 194×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- When adipose tissue expansion capacity is exceeded, lipid accumulates in non-adipose tissues (lipotoxicity), which directly causes insulin resistance and metabolic syndrome.Good
- Increasing the expression of PGC1a enhances fatty acid oxidation and mitochondrial function in peripheral tissues, which prevents lipotoxicity and improves insulin sensitivity.Good
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