Research
Hormonal
Elevated resistin levels are predictive of atherosclerosis, coronary artery disease (CAD), and adverse cardiovascular outcomes in humans, independent of traditional risk factors like CRP.
High resistin levels are associated with a higher risk of heart disease and stroke. While not a standalone diagnostic tool, it reflects underlying inflammation and vascular stress. Focus on proven cardiovascular health strategies: manage blood pressure, lipids, blood sugar, and avoid smoking.
GoodSupportsHIGH confidence
Indeed, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke.
Why this rating
Supported by multiple clinical studies and cohort analyses cited in the review.
Source
Resistin in Rodents and Humans
Hyeong Kyu Park et al. · Diabetes & Metabolism Journal · 2013
DOI 10.4093/dmj.2013.37.6.404
narrative_reviewCited 194×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- In rodents, resistin administration impairs glucose tolerance and insulin action, while resistin deletion improves insulin sensitivity and glucose homeostasis.Strong
- In rodents, resistin is an adipokine that directly causes insulin resistance and impairs glucose tolerance, whereas in humans, resistin is primarily secreted by macrophages and serves as a marker of inflammation rather than a direct cause of insulin resistance.Good
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