Hormonal
Substituting pro-aging carbon sources (glucose and ethanol) with glycerol in yeast mimics the life-span extension effects of calorie restriction by activating stress resistance pathways without triggering pro-aging signaling.
While this study is in yeast, it suggests that the type of fuel your body uses matters for longevity. Replacing high-glycemic fuels (like glucose/ethanol equivalents) with more stable metabolic byproducts (like glycerol in this context) can mimic the benefits of calorie restriction. For humans, this implies that managing insulin and nutrient-sensing pathways (Tor/Sch9 homologs) through diet composition, not just caloric restriction, is crucial for longevity.
Glycerol, unlike glucose or ethanol, did not adversely affect the life span extension induced by calorie restriction or starvation, suggesting that carbon source substitution may represent an alternative to calorie restriction as a strategy to delay aging.
Why this rating
High-quality genetic and metabolic data in a conserved model organism (S. cerevisiae), though not directly translatable to humans without further validation.
Source
Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension
Min Wei et al. · PLoS Genetics · 2009
DOI 10.1371/journal.pgen.1000467
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