Research
Adherence
FTO gene variants are associated with increased energy intake rather than energy expenditure, leading to a 3-4 kg higher body weight and 1.67-fold increased obesity risk in homozygotes.
If you have the FTO risk variant, be aware that you may have a genetic predisposition to eat more. Focus on managing energy intake through mindful eating strategies.
GoodSupportsHIGH confidence
Several human studies have demonstrated an association between SNPs in FTO and energy intake rather than energy expenditure. Homozygotes for the risk allele of the most common SNP in FTO are 3–4 kg heavier than those without the risk allele and have a 1.67-fold increased risk of obesity.
Why this rating
Based on GWAS studies with consistent findings across populations.
Source
Genetic approaches to understanding human obesity
Shwetha Ramachandrappa et al. · Journal of Clinical Investigation · 2011
narrative_reviewCited 193×
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