Hormonal
Men with type 2 diabetes exhibit specific insulin resistance in protein metabolism, characterized by a failure of protein synthesis to increase in response to hyperinsulinemia, whereas women with type 2 diabetes do not show this additive resistance beyond that caused by obesity alone.
If you have type 2 diabetes, your body's ability to use insulin to build muscle (protein synthesis) is specifically impaired, particularly if you are male. This isn't just about blood sugar; it's about how your muscles respond to food. Women with T2D may not share this specific synthesis resistance to the same degree as men. This suggests that protein intake strategies might need to be tailored by sex and diabetes status, rather than following a generic 'high protein' rule.
During our clamp, men with type 2 diabetes have greater insulin resistance of protein metabolism than that conferred by excess adiposity itself, whereas women do not.
Why this rating
Randomized controlled trial using hyperinsulinemic-euglycemic-isoaminoacidemic clamps, a gold-standard method for measuring kinetics, with matched controls.
Source
Insulin Resistance of Protein Metabolism in Type 2 Diabetes
Sandra Pereira et al. · Diabetes · 2007
DOI 10.2337/db07-0887
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