Research
Hormonal
Impaired kisspeptin signaling in adult male mice does not result in obesity or glucose intolerance, demonstrating a strong sexual dimorphism in metabolic regulation.
Metabolic consequences of kisspeptin signaling impairment appear to be specific to females in this model. Males with the same genetic impairment maintain normal body weight and glucose regulation.
GoodRefutesHIGH confidence
Conversely, male Kiss1r KO mice had normal BW and glucose regulation.
Why this rating
Consistent findings across standard chow and high-fat diet in male KO mice.
Source
Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity
Kristen P. Tolson et al. · Journal of Clinical Investigation · 2014
DOI 10.1172/jci71075
mechanism_onlyCited 192×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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