Hormonal

Increasing skeletal muscle expression of Estrogen-related Receptor gamma (ERRγ) via genetic overexpression or pharmacological agonism shifts muscle phenotype toward slow-twitch oxidative fibers, thereby increasing mitochondrial function and endurance exercise capacity.

This research suggests that targeting the ERRγ pathway could be a potential therapeutic strategy for conditions like obesity or sarcopenia, where oxidative metabolism is reduced. For now, exercise itself naturally induces ERRγ expression, which contributes to improved mitochondrial function and endurance. Future therapies might mimic this effect pharmacologically.