Macro partitioning
The LIPC -514C/T polymorphism's effect on HDL-C concentrations is conditional on dietary fat intake; specifically, the T allele increases HDL-C only when fat intake is >=30% of energy, whereas high fat intake decreases HDL-C in TT genotype carriers.
If you carry the LIPC -514 TT genotype, your HDL cholesterol levels may drop if you consume a low-fat diet (<30% of calories from fat). Conversely, if you consume a higher fat diet (>=30% of calories), this genotype is associated with higher HDL. This suggests that individuals with this specific genetic variant may not benefit from standard low-fat dietary recommendations for lipid management and might require personalized fat intake targets.
the T allele was associated with significantly greater HDL-C concentrations only in subjects consuming >=30% of energy from fat... When total fat intake was <30% of energy, mean HDL-C concentrations were lowest among those with the TT genotype
Why this rating
Large observational cohort (Framingham, n=2130) with rigorous statistical adjustment for confounders and familial relationships, showing strong dose-response interactions.
Source
Dietary Fat Intake Determines the Effect of a Common Polymorphism in the Hepatic Lipase Gene Promoter on High-Density Lipoprotein Metabolism
José M. Ordovás et al. · Circulation · 2002
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