Hormonal
Plasma estradiol (E2) levels are not associated with all-cause or ischemic heart disease (IHD) mortality in older men.
For older men, estradiol levels do not appear to be a predictor of survival or heart disease death. This suggests that strategies to optimize longevity in this age group should focus on testosterone and DHT rather than estradiol manipulation.
E2 was not associated with either all-cause or IHD mortality.
Why this rating
Large cohort, precise assays, and extensive adjustment for confounders.
Source
In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortality and Higher Dihydrotestosterone With Reduced Ischemic Heart Disease Mortality, While Estradiol Levels Do Not Predict Mortality
Bu B. Yeap et al. · The Journal of Clinical Endocrinology & Metabolism · 2013
DOI 10.1210/jc.2013-3272
More from this paper
- In older men (aged 70-89), mid-range plasma testosterone levels (specifically the 2nd and 3rd quartiles, approx. 9.8–15.8 nmol/L) are associated with the lowest all-cause mortality, indicating a U-shaped relationship where both very low and very high levels carry higher risk.Good
- In older men, higher plasma dihydrotestosterone (DHT) levels (above the median) are associated with significantly reduced ischemic heart disease (IHD) mortality, independent of testosterone levels.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →