Hormonal
Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance by allowing bacterial translocation into metabolic tissues.
This research suggests that for some individuals, insulin resistance may be driven by gut bacteria leaking into metabolic tissues due to specific immune system variations (NOD2). While this is a mouse study, it highlights that gut health and immune sensing are critical factors in metabolic disease, potentially beyond just calories.
We demonstrate that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insulin sensitivity... NOD2-/- mice have increased adipose tissue and liver inflammation and exacerbated insulin resistance during a HFD.
Why this rating
High-quality mechanistic evidence using knockout mice, clamps, and microbiota transfer, but results are specific to murine models.
Source
Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance
Emmanuel Denou et al. · EMBO Molecular Medicine · 2015
DOI 10.15252/emmm.201404169
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