Hormonal
In obese individuals, lower resting energy expenditure (REE) relative to predicted levels is associated with significantly lower circulating active ghrelin levels and reduced ghrelin activity.
If you are obese and struggling with weight loss, your body's hormonal response (ghrelin) may be suppressed more severely if your resting energy expenditure is low. This suggests that metabolic rate is a key factor in hunger regulation, and treatments or strategies that address metabolic efficiency might be more effective than those focusing solely on caloric intake.
Significantly higher active ghrelin levels (214 (cid:1) 22 vs. 159 (cid:1) 30 pg/ml; P < 0.05) and ghrelin activity (8 (cid:1) 1.7% vs. 4.9 (cid:1) 0.9%; P < 0.05) were observed in patients with positive compared with negative measured/predicted REE ratio values.
Why this rating
The study uses specific immunoassays and a controlled cohort, but the cross-sectional design limits causal inference.
Source
The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure
Paolo Marzullo et al. · The Journal of Clinical Endocrinology & Metabolism · 2004
DOI 10.1210/jc.2003-031328
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