Hormonal
Elevated baseline plasma copeptin levels do NOT independently predict the development of the full metabolic syndrome cluster, despite predicting its individual components (DM and abdominal obesity).
While high copeptin levels predict individual risks like diabetes and abdominal obesity, they do not predict the full metabolic syndrome cluster. This highlights the complexity of metabolic health and the importance of addressing individual risk factors rather than relying on a single biomarker for syndrome prediction.
After additional adjustment for all the MetS components at baseline, increasing copeptin quartiles predicted incident abdominal obesity... DM... and microalbuminuria... but not MetS (P for trend = 0.19) at the reexamination.
Why this rating
Same high-quality prospective cohort design.
Source
Copeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: the prospective Malmö Diet and Cancer Study cardiovascular cohort
Sofia Enhörning et al. · International Journal of Obesity · 2012
DOI 10.1038/ijo.2012.88
More from this paper
- Elevated baseline plasma copeptin levels independently predict the future development of type 2 diabetes and abdominal obesity, suggesting a primary role for the vasopressin system in cardiometabolic risk.Good
- Elevated baseline plasma copeptin levels independently predict the future development of microalbuminuria, even after adjusting for incident diabetes and hypertension.Good
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