Research
Hormonal
Intermittent fasting worsens glucose tolerance and induces beta-cell death in mice with lysosomal dysfunction (LAMP2 deficiency) or impaired autophagosome formation (BECN1 deficiency).
If you have underlying cellular recycling defects, fasting might damage your pancreas. Consult a doctor before trying IF if you have known metabolic disorders.
ModerateRefutesMEDIUM confidence
Intermittent fasting is sufficient to provoke beta cell death in non-obese lamp2 null mice... IF provoked impaired glucose tolerance in male lamp2 null mice fed a chow diet
Why this rating
Mouse model data.
Source
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway
Haiyan Liu et al. · Autophagy · 2017
DOI 10.1080/15548627.2017.1368596
mechanism_onlyCited 189×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Intermittent fasting preserves pancreatic beta-cell mass and improves glucose tolerance in obesity-induced diabetes by stimulating the autophagy-lysosome pathway.Moderate
- Intermittent fasting stimulates beta-cell regeneration markers (NEUROG3) in obesity-induced diabetes, but this effect is dependent on an intact autophagy-lysosome pathway.Moderate
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