Research
Hormonal
Excess adiposity, particularly visceral fat, is the central driver of the Cardiovascular-Renal-Hepatic-Metabolic (CRHM) syndrome, leading to insulin resistance, inflammation, and multi-organ dysfunction.
Managing excess body fat, especially around the waist, is the most important step in preventing heart, kidney, and liver disease. Reducing visceral fat reduces inflammation and improves insulin sensitivity, protecting your organs.
StrongSupportsVERY_HIGH confidence
The Central driver of this syndrome process is excess adiposity, which is characterized by chronic inflammation and drives the development of other CRHM risk factors, including arterial hypertension, T2DM, and dyslipidemia, while also promoting atherosclerosis, cardiac, renal and hepatic dysfunction.
Why this rating
The paper provides a detailed pathophysiological explanation linking adiposity to all major components of the syndrome.
Source
From Cardiovascular-Kidney-Metabolic Syndrome to Cardiovascular-Renal-Hepatic-Metabolic Syndrome: Proposing an Expanded Framework
Nikolaos Theodorakis et al. · Biomolecules · 2025
narrative_reviewCited 79×
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