Research
Hormonal
p53 positively regulates SIRT6 protein levels under normal growth conditions but is not required for the nutrient-dependent stabilization of SIRT6 during fasting.
Under normal eating conditions, the protein p53 helps maintain baseline levels of SIRT6. However, when you fast, your body uses a different mechanism to boost SIRT6 that doesn't rely on p53, suggesting multiple layers of protection.
GoodQualifiesHIGH confidence
p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6.
Why this rating
Clear experimental evidence using p53-deficient mice.
Source
Regulation of SIRT6 protein levels by nutrient availability
Yariv Kanfi et al. · FEBS Letters · 2008
DOI 10.1016/j.febslet.2008.01.019
mechanism_onlyCited 189×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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