Hormonal
Testosterone supplementation reverses age-related sarcopenia in mice by suppressing processed myostatin and JNK activation while stimulating Akt and Notch signaling pathways.
For aging individuals experiencing muscle loss, testosterone therapy may be a viable option to restore muscle mass and strength, particularly when combined with lifestyle interventions. Consultation with a healthcare provider is essential to determine suitability and monitor for potential side effects.
Testosterone reverses sarcopenia through stimulation of cellular metabolism and survival pathway together with inhibition of death pathway.
Why this rating
The study uses a controlled animal model with clear mechanistic pathways and statistical significance, but results are not directly translatable to humans without further clinical validation.
Source
Testosterone Supplementation Reverses Sarcopenia in Aging through Regulation of Myostatin, c-Jun NH2-Terminal Kinase, Notch, and Akt Signaling Pathways
Ekaterina Kovacheva et al. · Endocrinology · 2009
DOI 10.1210/en.2009-1177
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