Hormonal
Semaglutide 2.4 mg is a cost-effective treatment for obesity and overweight in the US, providing greater weight loss and QALYs than diet/exercise, no treatment, or other anti-obesity medications, provided the willingness-to-pay threshold is $150,000 per QALY.
For patients with obesity or overweight plus comorbidities, semaglutide 2.4 mg combined with diet and exercise is a cost-effective medical option in the US, offering significant weight loss and quality-adjusted life years compared to lifestyle changes alone or other medications, assuming a willingness-to-pay threshold of $150,000 per QALY.
Under a willingness-to-pay threshold of $150,000, semaglutide 2.4 mg was estimated to be cost-effective compared with no treatment, diet and exercise, and anti-obesity medications over a 30-year horizon.
Why this rating
Based on a Markov model using data from pivotal Phase 3 trials (STEP 1, 2, 4) and real-world evidence, though it is an economic model rather than a direct clinical trial.
Source
Cost-effectiveness analysis of semaglutide 2.4 mg for the treatment of adult patients with overweight and obesity in the United States
Nina Kim et al. · Journal of Managed Care & Specialty Pharmacy · 2022
DOI 10.18553/jmcp.2022.28.7.740
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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