Research
Hormonal
Sibutramine (10-30 mg/day) produces significant, dose-dependent weight loss in obese adults over 24 weeks when combined with caloric restriction and lifestyle modification, with effects reversing upon discontinuation.
Take sibutramine (10-30mg daily) alongside a strict diet (1200-1500 kcal) and daily exercise. Expect significant weight loss (9-12%) over 6 months, but understand that stopping the medication will likely lead to weight regain. This drug is a tool to help you lose weight, not a permanent fix.
GoodSupportsHIGH confidence
There was a dose-dependent reduction in body weight, with doses of 10, 15, 20 and 30 mg being significantly greater than placebo. Weight loss was still continuing in the highest three doses at the end of the study. When drugs were discontinued patients regained weight, as expected.
Why this rating
Double-blind, randomized, placebo-controlled trial with 173 subjects, though limited to 24 weeks.
Source
A Double‐Blind Randomized Placebo‐Controlled Trial of Sibutramine
George A. Bray et al. · Obesity Research · 1996
DOI 10.1002/j.1550-8528.1996.tb00544.x
rct · n=173Cited 189×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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