Research
Hormonal
Alpha-melanocyte-stimulating hormone (α-MSH) and Cocaine- and Amphetamine-Regulated Transcript (CART) reduce food intake and increase energy expenditure, acting as counter-regulatory peptides to NPY and AGRP.
α-MSH and CART help you feel full and burn energy. In obesity, these signals are often suppressed.
GoodSupportsHIGH confidence
...and decreased levels of α-melanocyte-stimulating hormone (α-MSH), cocaine and amphetamine-regulated transcript (CART) and neurotensin that reduce food intake and increase energy expenditure.
Why this rating
Supported by genetic mutations (POMC, MC-4R) causing obesity.
Source
Neuropeptides and appetite control
John Wilding · Diabetic Medicine · 2002
DOI 10.1046/j.1464-5491.2002.00790.x
narrative_reviewCited 188×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Neuropeptide Y (NPY) and Agouti-Related Protein (AGRP) are potent orexigenic peptides that increase food intake and decrease energy expenditure, particularly when leptin signaling is low.Good
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