Macro partitioning
Dietary restriction of specific amino acids, particularly methionine or general protein, inhibits mTORC1 signaling and extends rodent lifespan, offering a sustainable alternative to pharmacological mTOR inhibition.
Consider reducing overall protein intake or specifically restricting methionine (found in high amounts in meat, eggs, and some nuts) to potentially slow aging via mTORC1 inhibition. This can be achieved through plant-based diets which are often lower in methionine. This approach is safer and more sustainable than long-term pharmacological rapamycin use, though it requires careful planning to ensure adequate nutrition.
Recent studies have clearly shown that a low-protein diet significantly extends rodent life span and is associated with reduced cancer and mortality in humans... Diets restricted in specific amino acids are often used in the treatment of inborn errors of metabolism, suggesting that diets with reduced dietary protein or specific amino acids may be a sustainable intervention for a large population.
Why this rating
Strong evidence in rodents and observational human data, though mechanistic link to mTORC1 is noted as 'not clear' in some contexts.
Source
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin and Beyond
Dudley W. Lamming · Cold Spring Harbor Perspectives in Medicine · 2016
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