Hormonal
Myostatin induces reactive oxygen species (ROS) production in skeletal muscle cells via a feed-forward loop involving NF-κB activation, TNF-α upregulation, and NADPH oxidase (Nox1) expression, leading to muscle wasting.
This research highlights a biological mechanism where the protein myostatin triggers oxidative stress and inflammation in muscle, leading to muscle loss. While this is a natural process in aging or disease, it suggests that targeting the inflammatory pathway (NF-κB/TNF-α) might help preserve muscle mass, rather than just focusing on exercise or nutrition alone.
Our results here show that Mstn induces oxidative stress by producing ROS in skeletal muscle cells through tumor necrosis factor-a (TNF-a) signaling via NF-jB and NADPH oxidase.
Why this rating
Strong experimental evidence using cell lines (C2C12) and knockout mice (Mstn-/-), with inhibitor studies confirming pathway specificity.
Source
Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF‐κB
Sandhya Sriram et al. · Aging Cell · 2011
DOI 10.1111/j.1474-9726.2011.00734.x
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