Hormonal
Musclin, an exercise-stimulated myokine, enhances physical endurance and aerobic capacity by potentiating ANP signaling to increase cGMP, thereby promoting PGC1-α-dependent mitochondrial biogenesis in skeletal muscle.
This research identifies musclin as a key messenger released by muscles during exercise that helps build mitochondria, the energy powerhouses of cells. While musclin itself is not currently available as a therapeutic, the findings reinforce that physical activity triggers specific hormonal responses that improve endurance. To boost this pathway, engage in regular aerobic exercise, which naturally stimulates musclin production and subsequent mitochondrial biogenesis.
Together, these data indicate that musclin enhances physical endurance by promoting mitochondrial biogenesis.
Why this rating
Strong mechanistic evidence in mice and cell culture, but lacks human clinical trials for efficacy.
Source
Musclin is an activity-stimulated myokine that enhances physical endurance
Ekaterina Subbotina et al. · Proceedings of the National Academy of Sciences · 2015
DOI 10.1073/pnas.1514250112
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