Hormonal
Hormonal Replacement Therapy (HRT) reduces visceral fat mass and improves insulin sensitivity in postmenopausal women, particularly when initiated during perimenopause or early menopause.
If you are going through menopause and concerned about weight gain, talk to your doctor about Hormonal Replacement Therapy (HRT). Starting HRT early (during perimenopause or shortly after menopause) can help reduce belly fat and improve how your body handles sugar. However, this should be combined with a healthy diet and exercise, and only done if your doctor determines it is safe for you.
Indeed, there is a lot of evidence that hormonal replacement therapy (currently called hormonal therapy of menopause [HTM]) reduces obesity, decreases abdominal fat mass (redistributes body fat), lowers the fasting glucose and insulin levels, improves blood lipid profile and, as a result, reduces cardiovascular risk [25, 26].
Why this rating
The paper cites a meta-analysis of over 100 RCTs, indicating high-quality evidence.
Source
Obesity in menopause – our negligence or an unfortunate inevitability?
Jarosław Kozakowski et al. · Menopausal Review · 2017
DOI 10.5114/pm.2017.68594
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →