Research
Hormonal
Growth hormone does not accelerate fat loss in obese subjects during caloric restriction, despite increasing free fatty acid (FFA) mobilization.
Do not use Growth Hormone expecting it to help you lose more fat. It increases the amount of fat in your blood temporarily, but it does not help you lose more body fat than dieting alone. It is not an effective fat-loss strategy.
GoodRefutesHIGH confidence
GH produced no significant acceleration of fat loss.
Why this rating
RCT with objective body composition measures (hydrostatic weighing, skinfolds).
Source
Treatment of Obese, Diet-Restricted Subjects with Growth Hormone for 11 Weeks: Effects on Anabolism, Lipolysis, and Body Composition*
David K. Snyder et al. · The Journal of Clinical Endocrinology & Metabolism · 1988
DOI 10.1210/jcem-67-1-54
rct · n=20Cited 185×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Growth hormone (GH) administration during caloric restriction preserves lean body mass (nitrogen retention) for approximately 5 weeks, after which the anabolic effect is lost despite continued GH treatment.Good
- Growth hormone causes fluid retention (edema) and weight gain in the first week of treatment, which resolves after treatment stops, resulting in no net difference in total weight loss compared to placebo.Good
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