Hormonal
Hepatocyte MyD88 regulates bile acid synthesis and profile, which in turn influences gut microbiota composition and host glucose/lipid metabolism.
Your liver produces bile acids that act as hormones, influencing your gut bacteria and how you process sugar and fat. Disruptions in liver signaling (like inflammation) can alter these bile acids, potentially worsening metabolic health. A diet low in excessive fats may help maintain healthier bile acid profiles.
Hepatocyte MyD88 controls the synthesis of bioactive lipids involved in glucose, lipid metabolism and inflammation. Hepatocyte MyD88 regulates the transcriptional activity of several genes involved in bile acid metabolism.
Why this rating
Strong mechanistic evidence linking gene expression, bile acid profiles, and microbiota changes.
Source
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism
Thibaut Duparc et al. · Gut · 2016
DOI 10.1136/gutjnl-2015-310904
More from this paper
- Hepatocyte-specific deletion of MyD88 causes glucose intolerance, hepatic insulin resistance, and inflammation independently of body weight or fat mass gain.Good
- Obese humans with Non-Alcoholic Steatohepatitis (NASH) exhibit decreased expression of cytochromes P450 involved in bioactive lipid synthesis, mirroring findings in MyD88-deficient mice.Moderate
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