Research
Adherence
Lifestyle modification (diet and exercise) is the first-line therapy for dyslipidemia in PCOS, and statins are a novel therapeutic approach that improves lipid profiles and reduces testosterone and insulin resistance.
Start with diet and exercise as your primary treatment for PCOS-related lipid issues. If your LDL remains high (above 160 mg/dL) or non-HDL-C is high (above 190 mg/dL) despite lifestyle changes, discuss statins with your doctor. Statins can help lower both cholesterol and testosterone/insulin resistance, but you must use contraception if taking them.
StrongSupportsVERY_HIGH confidence
Lifestyle modification, including diet and exercise, is the first line therapy for all women with PCOS and is particularly important for those with dyslipidemia... Statin drugs are used when lifestyle modifications are not enough... PCOS women receiving statins showed a significant decrease of testosterone, free androgen index, C-reactive protein, and insulin resistance
Why this rating
Based on consensus guidelines (AE-PCOS Society) and multiple randomized controlled trials cited.
Source
Dyslipidemia in women with polycystic ovary syndrome
Jinju Kim et al. · Obstetrics & Gynecology Science · 2013
narrative_reviewCited 185×
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