Hormonal
Dietary supplementation with Allium cepa (onion) extracts, particularly those rich in quercetin and organosulfur compounds, inhibits adipogenesis and promotes browning of white adipose tissue, leading to reduced fat accumulation and improved lipid profiles in preclinical models.
Incorporating onion peel extracts or quercetin-rich onion preparations into your diet may support metabolic health by inhibiting the formation of new fat cells and promoting the browning of white fat. While not a magic bullet for weight loss, it serves as a supportive dietary strategy for managing lipid profiles and insulin sensitivity, particularly when combined with a balanced diet.
Moon and colleagues demonstrated that quercetin-rich onion peel extract is able to suppress preadipocyte differentiation and to inhibit adipogenesis... The ability to suppress adipogenesis of quercetin-rich onion peel extract was further investigated by Bae and colleagues... onion peel extract could suppress adipogenesis by down-regulating PPAR-γ and C/EBPα... Lee and co-workers reported that onion is able to modify the characteristics of white adipocytes to those of brown-like adipocytes both in vivo... and in vitro.
Why this rating
The evidence is primarily from in vitro and in vivo animal studies (rats/mice); human data is limited to small clinical trials with mixed outcomes on weight/BP.
Source
Biological Properties and Bioactive Components of Allium cepa L.: Focus on Potential Benefits in the Treatment of Obesity and Related Comorbidities
Mariangela Marrelli et al. · Molecules · 2018
DOI 10.3390/molecules24010119
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