Hormonal
Overexpression of caveolin-1 in adipocytes increases caveolae density, enhances insulin-stimulated glucose uptake, and allows for larger lipid droplet storage.
This paper explains the cellular machinery behind fat storage. High levels of caveolin-1 help fat cells store more fat and process glucose better. This is a biological mechanism, not a direct advice for humans to manipulate, but it explains why some people store fat more easily than others.
Caveolin-1 expression as a crucial step in adipose cell lines and in mice to raise the density of caveolae, to increase adipocyte ability to accommodate larger lipid droplets, and to promote cell expansion by increased glucose utilization.
Why this rating
Strong mechanistic evidence from cell culture and mouse models, but no direct human intervention testing caveolin-1 overexpression.
Source
Caveolin-1 Expression and Cavin Stability Regulate Caveolae Dynamics in Adipocyte Lipid Store Fluctuation
Nolwenn Briand et al. · Diabetes · 2014
DOI 10.2337/db13-1961
More from this paper
- Sustained lipid mobilization (fat loss) leads to the disassembly of caveolae through the degradation of cavin proteins (cavin-1, cavin-2, EHD2), reducing caveolae density.Strong
- Higher baseline expression of caveolin-1 in adipocytes enables greater hypertrophic expansion (fat cell enlargement) in response to caloric overfeeding in healthy humans.Good
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