Hormonal
SGLT2 inhibitors lower blood glucose in Type 2 Diabetes by blocking renal glucose reabsorption, resulting in increased urinary glucose excretion without causing hypoglycemia.
If you have Type 2 Diabetes, SGLT2 inhibitors are a class of medication that helps your kidneys remove excess sugar through urine. This lowers blood sugar and can help with weight loss, without the risk of dangerously low blood sugar (hypoglycemia) common in other treatments. Be aware of a higher risk for urinary or fungal infections.
SGLT2 inhibitors... block glucose reabsorption and thus promote increased urinary glucose excretion (UGE)... This insulin-independent mechanism decreases blood pressure, individual weight and plasma glucose levels without causing hypoglycemia
Why this rating
The paper cites multiple clinical studies and market approvals, though it is a review paper.
Source
Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome—Review of Classical and New Compounds: Part-I
Raquel Vieira et al. · Pharmaceuticals · 2019
DOI 10.3390/ph12040152
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