Macro partitioning
Orlistat is the only currently available long-term pharmacological treatment for obesity in Europe because it offers a favorable safety profile regarding cardiovascular events and diabetic control, despite being less effective for weight reduction than withdrawn agents.
Take Orlistat (120mg Rx or 60mg OTC) with your three main meals containing fat. If a meal has no fat, skip the dose. Stick to a diet where about 30% of calories come from fat to minimize gastrointestinal side effects, which usually improve over time. Stop the medication if you haven't lost at least 5% of your body weight after 12 weeks.
Orlistat is the only available long-term treatment for obesity... Orlistat is a good choice for the treatment of obesity, because of its safety on cardiovascular events and its positive effects on diabetic control, even if it is not as effective as rimonabant or sibutramine in reducing body weight.
Why this rating
Based on a systematic review of randomized controlled trials and multiple cited studies showing consistent weight loss and metabolic improvements.
Source
Anti-obesity drugs: a review about their effects and their safety
Giuseppe Derosa et al. · Expert Opinion on Drug Safety · 2012
DOI 10.1517/14740338.2012.675326
More from this paper
- Sibutramine and Rimonabant, previously approved anti-obesity drugs, were withdrawn from the market due to serious adverse effects, specifically increased cardiovascular risk and psychiatric disorders, respectively.Strong
- GLP-1 receptor agonists (Exenatide and Liraglutide) are marketed drugs that suppress appetite and reduce body weight while improving glycemic control in diabetic patients.Good
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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