Macro partitioning
Orlistat is the only currently available long-term pharmacological treatment for obesity in Europe because it offers a favorable safety profile regarding cardiovascular events and diabetic control, despite being less effective for weight reduction than withdrawn agents.
Take Orlistat (120mg Rx or 60mg OTC) with your three main meals containing fat. If a meal has no fat, skip the dose. Stick to a diet where about 30% of calories come from fat to minimize gastrointestinal side effects, which usually improve over time. Stop the medication if you haven't lost at least 5% of your body weight after 12 weeks.
Orlistat is the only available long-term treatment for obesity... Orlistat is a good choice for the treatment of obesity, because of its safety on cardiovascular events and its positive effects on diabetic control, even if it is not as effective as rimonabant or sibutramine in reducing body weight.
Why this rating
Based on a systematic review of randomized controlled trials and multiple cited studies showing consistent weight loss and metabolic improvements.
Source
Anti-obesity drugs: a review about their effects and their safety
Giuseppe Derosa et al. · Expert Opinion on Drug Safety · 2012
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